Heart failure & cardiomyopathies
Long-Term Cumulative High-Sensitivity Cardiac Troponin T and Mortality Among Patients with Acute Heart Failure
Authors' conclusion
Elevated cumulative hs-cTNT from admission to 12 months after discharge was independently associated with mortality after 12 months among patients with acute HF.
Study context
- Population
- Patients hospitalised for acute heart failure (HF) who survived 12 months with high-sensitivity cardiac troponin T (hs-cTNT) at admission and 1 and 12 months after discharge (China PEACE 5p-HF Study, 2016–2018)
- Participants
- 1,137 patients
- Exposure
- Quartiles of cumulative hs-cTNT and cumulative times of high hs-cTNT level
- Zero timesn = 404reference
- One timen = 203
- Two timesn = 174
- Three timesn = 356
- Outcome
- All-cause mortality after 12 months
- Follow-up
- Median 4.76 (IQR, 4.25-5.07) years
Methodological detailsmulticentre, 52 hospitals
- Multicentre
- 52 hospitals
Main finding
As reported in the abstract
All-cause mortality
Hazard ratio (95% CI)
Quartile 4vs Quartile 1
4.14(2.51–6.85)
Quartile 3vs Quartile 1
3.35(2.05–5.48)
Quartile 2vs Quartile 1
2.47(1.49–4.08)
One timevs Zero time
1.60(1.05–2.45)
Two timesvs Zero time
2.61(1.76–3.87)
Three timesvs Zero time
2.86(1.98–4.14)
- All-cause deaths
- 303 (26.6%)
- Median cumulative hs-cTNT level (IQR 91-241)
- 150 ng/L*month
Observational data: associations, not effects.
Original publication
Long-Term Cumulative High-Sensitivity Cardiac Troponin T and Mortality Among Patients with Acute Heart Failure. ESC Heart Fail. Published 3 March 2023. doi:10.
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