Arrhythmias & electrophysiology

Long-Term Freedom From Ventricular Arrhythmias in Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) With Endocardial Only Ablation: Predictors of Success

JACC Clin ElectrophysiolPublished Retrospective cohort study

Authors' conclusion

Long-term VT-free survival can be achieved in over half of ARVC patients following ENDO-only VT ablation, increasing to over 75% if VT noninducibility is achieved.

Study context

Population
Patients with ARVC (Task Force Criteria) undergoing first endocardial-only ventricular tachycardia (VT) ablation, 1998–2020
Participants
74 patients
Outcome
Freedom from any recurrent sustained VT after the last endocardial (ENDO)-only ablation
Methodological detailsconsecutive patients
  • Consecutive patients

Main finding

As reported in the abstract

Freedom from any recurrent sustained VT after last ENDO-only ablation · median follow-up 6.6 years (Q1-Q3: 3.4-11.2 years)

Patients free from any VT recurrence

40

54.1%

Additional patients with rare VT (≤2 episodes)

12.2%

Observational data: associations, not effects.

Further findings

VT noninducibility after ablation

VT noninducibility achieved
49 (66%)

VT-free survival among patients with noninducibility · long-term follow-up

VT-free survival with noninducibility
75.5%

Predictors of VT-free survival (multivariable analysis)

>45 y of age at diagnosis, HR
0.41 (0.17-0.98) (95% CI)
VT noninducibility, HR
0.36 (0.16-0.80) (95% CI)
  • Multivariable analysis

Original publication

Long-Term Freedom From Ventricular Arrhythmias in ARVC With Endocardial Only Ablation: Predictors of Success. JACC Clin Electrophysiol. Published 16 May 2024. doi:10.1016/j.jacep.2024.05.003

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