Mapping organ fat distribution and body composition: towards precision profiling of cardiometabolic disease risk
Authors' conclusion
Distinct patterns of multi-organ fat accumulation were associated with differential body composition, cardiac remodelling, and cardiometabolic disease risk profiles.
Study context
- Population
- UK Biobank participants without overt cardiac disease6 phenotypic groups
- Participants
- 24,935 participants
- Exposure
- Adiposity phenotypic groups by organ-dominant fat accumulation
- Outcome
- Organ-dominant fat accumulation, body composition, cardiac remodelling and cardiometabolic disease risk, by adiposity phenotype
Methodological detailsunsupervised clustering, MRI-derived adiposity measures
- Unsupervised clustering
- MRI-derived adiposity measures
Main finding
As reported in the abstract
- Each phenotype showed distinct organ-dominant fat accumulation and body composition pattern
- Pancreatic fat dominant phenotype (visceral adiposity, sarcopenic features): cardiorenal-metabolic risk profile
- Muscle fat dominant phenotype (subcutaneous adiposity, sarcopenic features): associated with increased HF risk
- Pericardial fat dominant and liver fat dominant phenotypes: no association with cardiac disease risk, but distinctive cardiac remodelling patterns
- Normal-weight individuals with mild multi-organ fat: elevated chronic ischaemic heart disease risk
Observational data: associations, not effects.
Original publication
Mapping organ fat distribution and body composition: towards precision profiling of cardiometabolic disease risk. Eur Heart J. Published 31 August 2026. doi:10.
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