Maternal and neonatal outcomes in Marfan syndrome: a nationwide registry
Authors' conclusion
MFS pregnancies carry high risks of aortic complications and maternal mortality, persisting into long-term follow-up. Neonatal outcomes are also adversely affected.
Study context
- Population
- Pregnancies identified from national health databases in Taiwan, 2004–20222,073,560 women
- Participants
- 3,337,969 pregnancies
- Exposure
- Marfan syndrome (MFS) vs non-MFS pregnancies
- MFSn = 794
- Outcome
- Maternal outcomes: severe aortic complications, 42-day and late maternal mortality, long-term CV events; neonatal outcomes
Methodological detailsnationwide, national health databases, Taiwan
- Nationwide
- National health databases, Taiwan
Main finding
As reported in the abstract
Severe aortic complications and 42-day maternal mortality
Severe aortic complications
42-day maternal mortality
Observational data: associations, not effects.
Further findings
| Outcome | IRR (95% CI) | |
|---|---|---|
| Long-term maternal outcomes · mean 10.7-year follow-upMFSvs Non-MFSComposite aortic events | 885.4 (629.3–1245.6) | |
| Long-term maternal outcomes · mean 10.7-year follow-upMFSvs Non-MFSLate maternal mortality | 5.1 (3.1–8.7) | |
| 0.050.21520Incidence rate ratio (log scale) |
Neonatal outcomes
- Neonates of MFS mothers: lower gestational age and birth weight, higher risk of complications requiring intensive care
Original publication
Maternal and neonatal outcomes in Marfan syndrome: a nationwide registry. Heart. Published 31 December 2025. doi:10.
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