Heart failure & cardiomyopathies
Metabolic Profiling Identifies 1-MetHis and 3-IPA as Potential Diagnostic Biomarkers for Patients With Acute and Chronic Heart Failure With Reduced Ejection Fraction
Authors' conclusion
Our study provides novel insights into the metabolic differences between ADHF and CHF and healthy controls.
Study context
- Population
- Patients with acute decompensated or chronic HF and healthy controls
- Participants
- 15 / 50 / 13
- Exposure
- Acute decompensated heart failure (ADHF) and chronic heart failure (CHF) vs healthy controls
- ADHFn = 15
- CHFn = 50
- Controlsn = 13reference
- Outcome
- Metabolites distinguishing patients from controls
Main finding
As reported in the abstract
AUC for 3-indolepropionic acid and 1-methyl histidine (control vs patients)
≥0.8
Observational data: associations, not effects.
Further findings
Mean
| Outcome | ADHF | CHF | P value |
|---|---|---|---|
| Symmetrical dimethylarginine (ADHF vs control) | 1.97 (SD 0.61) | — not stated in the abstract | P = 0.01 |
| Kynurenine (CHF vs control) | — not stated in the abstract | 1.69 (SD 0.39) | P = 0.009 |
— not stated in the abstract
- Symmetrical dimethylarginine (ADHF vs control) — AUC
- ≥0.85
- Kynurenine (CHF vs control) — AUC
- ≥0.85
Original publication
Metabolic Profiling Identifies 1-MetHis and 3-IPA as Potential Diagnostic Biomarkers for Patients With Acute and Chronic Heart Failure With Reduced Ejection Fraction. Circ Heart Fail. Published 5 January 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →