Heart failure & cardiomyopathies
MicroRNAs are Associated with Cardiac Biomarkers, Cardiac Structure and Function and Incident Outcomes in Heart Failure
Authors' conclusion
Biomarkers and miRNA PCs are associated with cardiac structure and function and incident cardiovascular outcomes. Combining information from miRNAs provides prognostic information beyond biomarkers in HF.
Study context
- Population
- Individuals with symptomatic heart failure (HF)45 events
- Participants
- 139 individuals
- Outcome
- Association of plasma miRNAs and biomarkers (NT-proBNP, cardiac troponin I, suPAR, galectin-3) with echocardiographic ventricular size and function and incident composite of HF hospitalization, heart transplant, LV assist device implant or death
- Follow-up
- Median 368 days
Methodological details32 plasma microRNAs (miRNAs) quantified by FirePlex assay; principal component analysis, linear regression and Cox modelling
- 32 plasma miRNAs quantified by FirePlex assay; principal component analysis, linear regression and Cox modelling
Main finding
As reported in the abstract
- NT-proBNP with baseline LVEF
- β = −2.0; P = 0.001
- miRNA PC2 with baseline LVEF
- β = 2.6; P = 0.002
- NT-proBNP with baseline LV end-diastolic volume
- β = 20.6; P = 0.0004
- suPAR with baseline LV end-diastolic volume
- β = −39.6; P = 0.005
- PC4 with baseline LV end-diastolic volume
- β = 21.1; P = 0.02
- NT-proBNP with incident events
- HR 1.67, 95% CI 1.28-2.18, P = 0.0002
- Galectin-3 with incident events
- HR 2.02, 95% CI 1.05-3.91, P = 0.036
- PC3 with incident events
- HR 1.75, 95% CI 1.23-2.49, P = 0.002
- PC4 with incident events
- HR 1.67, 95% CI 1.1-2.52, P = 0.016
Observational data: associations, not effects.
Original publication
MicroRNAs are Associated with Cardiac Biomarkers, Cardiac Structure and Function and Incident Outcomes in Heart Failure. ESC Heart Fail. Published 6 February 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →