Valvular & structural heart diseaseCohort study
Mitral Transcatheter Edge-to-Edge Repair for Secondary Mitral Regurgitation With Preserved Left Ventricular Function
- Registry-based observational cohort study
- risk-adjusted
Authors' conclusion
In patients with sMR and preserved LVEF, MTEER was associated with a high rate of technical success, a low rate of complications, and large improvements in health status.
Study context
- Population
- Patients undergoing mitral transcatheter edge-to-edge repair (MTEER) for secondary mitral regurgitation, STS/ACC TVT Registry
- Participants
- 12,083 patients
- Exposure
- Left ventricular ejection fraction (LVEF) >50% vs LVEF 20% to 50%
- LVEF >50%n = 3,011
- LVEF 20% to 50%n = 9,072reference
Main finding
Outcomes of MTEER, LVEF >50% vs LVEF 20% to 50% · 1 year
Adjusted hazard ratio
0.81
95% CI 0.68–0.97
P = 0.02
LVEF >50% vs LVEF 20% to 50%
adjusted HR 0.81 (95% CI 0.68–0.97); P = 0.02
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | Values | adjusted HR (95% CI) | P value | |
|---|---|---|---|---|
| Moderate vs ≤ mild residual MR (LVEF >50%) · 1 year — Moderate MR vs ≤ mild MR · death | 1.46 (1.01–2.10) | P = 0.04 | ||
| Moderate vs ≤ mild residual MR (LVEF >50%) · 1 year — Moderate MR vs ≤ mild MR · HF hospitalization | 1.82 (1.32–2.52) | P < 0.001 | ||
| 0.20.5125Adjusted hazard ratio (log scale) |
| Outcome | Values | Estimate | P value |
|---|---|---|---|
| Residual MR grade (LVEF >50% subgroup) | ≤ mild MR 76.0% · Moderate MR 19.0% | ||
| KCCQ score improvement by residual MR grade (LVEF >50%) · 1 year | ≤ mild MR 28.7 ± 26.8 · Moderate MR 25.7 ± 27.2 · > moderate MR 21.6 ± 12.0 |
- KCCQ score improvement by residual mitral regurgitation (MR) grade (LVEF >50%): all P < 0.05
Original publication
Mitral Transcatheter Edge-to-Edge Repair for Secondary Mitral Regurgitation With Preserved Left Ventricular Function. JACC Cardiovasc Interv. Published 11 November 2024. doi:10.1016/j.jcin.2024.08.031
Summarised from the published abstract; every number is checked against it