Valvular & structural heart disease
Mortality Burden for Patients With Untreated Aortic Regurgitation
Authors' conclusion
In patients with untreated AR, LV remodeling, left atrial remodeling, and other markers of cardiac damage are associated with substantial mortality risk, both for severe and moderate AR.
Study context
- Population
- Adults (>18 years) with documented aortic regurgitation (AR) assessment not treated with aortic valve replacement (AVR), real-world data set from 27 US institutions
- Participants
- 81,378 adults
- Exposure
- AR severity and clinical factors vs mortality in untreated AR
- Outcome
- Untreated mortality
Methodological details27 US institutions, multivariable Cox analysis
- 27 US institutions
- Multivariable Cox analysis
Main finding
As reported in the abstract
Mortality (untreated AR)
Hazard ratio (95% CI)
Moderate AR
1.26(1.18–1.35)
Severe AR
2.37(1.96–2.87)
LV ejection fraction ≤55%
1.09(1.02–1.15)
LV dilation
1.34(1.21–1.48)
Left atrial dilation
1.09(1.03–1.16)
AF
1.11(1.04–1.17)
Elevated B-type natriuretic peptide/N-terminal pro-B-type natriuretic peptide
1.71(1.60–1.84)
Observational data: associations, not effects.
Original publication
Mortality Burden for Patients With Untreated Aortic Regurgitation. JACC Adv. Published 6 September 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →