Arrhythmias & electrophysiology

Multipolar radiofrequency ablation: Early experience with a novel approach to target intramural ventricular arrhythmias

Heart RhythmPublished observational retrospective case series

Authors' conclusion

MPA may facilitate arrhythmia control in patients with intramural VAs. Nevertheless, additional studies are necessary to better evaluate MPA safety and efficacy profiles, with further preclinical work and larger clinical studies required.

Study context

Population
Patients with refractory ventricular arrhythmias with evidence of intramural origin by defined mapping criteria, treated with multipolar ablation (MPA)consecutive patients who underwent 36 MPA procedures · MPA procedures for premature ventricular contractions 20 · MPA procedures for ventricular tachycardia 16
Participants
31 patients
Outcome
MPA lesion delivery
Methodological detailsconsecutive patients
  • Consecutive patients

Main finding

As reported in the abstract

MPA lesions delivered
151
Radiofrequency ablation (RFA)
60 s
Power
22 W
Initial current
379 mA
Impedance drop
19 Ω

Observational data: associations, not effects.

Further findings

Technical limitations of lesion delivery

High impedance in coronary sinus branches
Char formation on return electrodes

Success

Cases

Acute success
34 (94%)
Near-term success
25 (69%)
Long-term success
23 (70%)

Original publication

Multipolar radiofrequency ablation: Early experience with a novel approach to target intramural ventricular arrhythmias. Heart Rhythm. Published 7 August 2025. doi:10.1016/j.hrthm.2025.08.005

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