Non-cardiac birth defects and long-term risk of cardiovascular hospitalisation
Authors' conclusion
The findings suggest that both cardiac and non-cardiac birth defects are associated with an increased risk of developing cardiovascular disease among parous women.
Study context
- Population
- Parous women in Quebec, Canada, 1989–2022
- Participants
- 1,451,409 women
- Exposure
- Cardiac and non-cardiac birth defects vs no defect
- Outcome
- Hospitalisation for CAD, ischaemic stroke and other CV outcomes
- Follow-up
- 33 years
Methodological detailsCox proportional hazards regression, adjusted for patient characteristics
- Cox proportional hazards regression
- Adjusted for patient characteristics
Main finding
As reported in the abstract
CV hospitalisation
Hazard ratio (95% CI)
Non-cardiac defectsvs No defectnon-cardiac defects overall
1.61(1.56–1.66)
Urinary defectsvs No defectisolated urinary defects
3.93(3.65–4.23)
Central nervous system defectsisolated central nervous system defects
3.33(2.94–3.76)
Digestive defectsisolated digestive defects
2.39(2.16–2.65)
Heart defectsvs No defectgreatest risk
10.30(9.86–10.75)
Observational data: associations, not effects.
Original publication
Non-cardiac birth defects and long-term risk of cardiovascular hospitalisation. Heart. Published 15 May 2024. doi:10.
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