Nonobese young females with polycystic ovary syndrome are at high risk for long-term cardiovascular disease
Main finding · CVDResult — go to the resultHazard ratio 1.77 95% CI 1.19–2.65Authors' conclusion
Patients with PCOS had an increased risk of CVD
Study context
- Population
- Females in UK Biobank, recruited 2006–2010UK Biobank
- Participants
- 3,864 females
- Exposure
- Polycystic ovary syndrome (PCOS) vs no PCOS
- PCOSn = 645
- Outcome
- Long-term CVD
Methodological detailsUK Biobank, polygenic risk scores, proteomics subgroup cohort
- UK Biobank
- Polygenic risk scores
- Proteomics subgroup cohort
Main finding
CVD
Hazard ratio
1.77
95% CI 1.19–2.65
PCOSvs Without PCOS
HR 1.77 (95% CI 1.19–2.65)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| CAD | 2.27 (1.35–3.81) | |
| MI | 2.08 (1.11–3.90) | |
| 0.20.5125Hazard ratio (log scale) |
Cardiovascular disease (CVD) risk, young nonobese PCOS (subgroup)
- Risk especially high in young nonobese PCOS patients
- P for interaction < 0.05
- Interaction P<0.05
CVD incidence by PCOS treatment
- Current commonly used treatments did not affect CVD incidence
Proteomic biomarker
- DCBLD2 may be a specific CVD biomarker in PCOS
Original publication
Nonobese young females with polycystic ovary syndrome are at high risk for long-term cardiovascular disease. Eur J Prev Cardiol. Published 20 November 2024. doi:10.
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