Arrhythmias & electrophysiology
Nonoptimal Temperature Is Associated With Higher Atrial Fibrillation Hospitalizations in China: A Nationwide Case-Crossover Study
Authors' conclusion
In this nationwide sample, extreme cold temperatures were associated with a greater risk of AF hospitalization. Excess risk was observed in northern China, where low temperatures prevail.
Study context
- Population
- Atrial fibrillation (AF) patients in a nationwide registry, 251 cities in China, 2014–2023251 cities
- Participants
- 1,665,014 patients
- Exposure
- Nonoptimal vs minimum hospitalization temperature
- Outcome
- AF hospitalizations
- Follow-up
- Cumulative over lag 0–14 days
Methodological detailstwo-stage, nationwide registry, 251 cities
- Two-stage
- Nationwide registry
- 251 cities
Main finding
As reported in the abstract
AF hospitalization · lag 0 to 14 days
Cumulative RR (95% CI)
Extreme coldvs Minimum hospitalization temperature
1.32(1.24–1.42)
Extreme heatvs Minimum hospitalization temperature
1.03(0.99–1.07)
- Minimum hospitalization temperature for AF
- 24.3 °C (74th percentile)
Observational data: associations, not effects.
Further findings
Extreme-temperature hospitalization risk by age, sex and baseline diseases (subgroups)
- Similar across subgroups of age, sex and baseline diseases
AF admissions attributable to nonoptimal temperatures
- Overall attributable fraction (95% eCI 12.2%-14.8%)
- 14.3%
- Northern China (95% eCI 15.7%-19.4%)
- 18.4%
- Southern China (95% eCI 9.6%-13.6%)
- 12.4%
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Nonoptimal Temperature Is Associated With Higher Atrial Fibrillation Hospitalizations in China: A Nationwide Case-Crossover Study. JACC Adv. Published 16 September 2025. doi:10.
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