Valvular & structural heart disease
Number of calcified aortic valve leaflets: natural history and prognostic value in patients undergoing haemodialysis
Authors' conclusion
The number of calcified aortic valve leaflets strongly predicted AS development and even mortality in patients undergoing haemodialysis
Study context
- Population
- Patients undergoing haemodialysis without aortic stenosis (AS)709 (47%) with aortic sclerosis
- Participants
- 1,507 patients
- Exposure
- Number of calcified aortic valve leaflets
- One-leaflet calcifiedn = 370reference
- Two-leaflet calcifiedn = 215
- Three-leaflet calcifiedn = 124
- Outcome
- AS development and mortality
- Follow-up
- median 3.2-year follow-up
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
AS development
Adjusted hazard ratio (95% CI)
Two-leaflet calcifiedvs One-leaflet calcified
2.12(1.49–3.00)
Three-leaflet calcifiedvs One-leaflet calcified
4.43(3.01–6.52)
Per one calcified leaflet increase
2.24(1.96–2.55)
- Patients developing AS
- 251 (17%)
Observational data: associations, not effects.
Further findings
| Outcome | aHR (95% CI) | |
|---|---|---|
| All-cause mortality | 1.18 (1.08–1.27) | |
| 0.512Adjusted hazard ratio (log scale) |
Calcification progression
- Median time for one calcified leaflet increase
- 3-4 years
Original publication
Number of calcified aortic valve leaflets: natural history and prognostic value in patients undergoing haemodialysis. Eur Heart J Cardiovasc Imaging. Published 24 February 2023. doi:10.
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