Arrhythmias & electrophysiology
Obesity Cardiomyopathy in Sudden Cardiac Death: A Distinct Entity? A Comparative Study
Authors' conclusion
OCM may be a specific pathological entity associated with SCD. It is most commonly seen in young males with increased BMI.
Study context
- Population
- Sudden cardiac death (SCD) cases at autopsyof 6,457 SCD cases
- Participants
- 53 / 106 / 106
- Comparison
- Obesity cardiomyopathy (OCM) with SCD vs SCD controls with obesity or normal weight and morphologically normal hearts
- OCMn = 53
- Controls with obesityn = 106reference
- Normal weight controlsn = 106reference
- Outcome
- Clinical and pathological features of OCM
Methodological detailssex and age matched
- Sex and age matched
Main finding
As reported in the abstract
| Group | Value | Mean age at death | Male | BMI | LV fibrosis |
|---|---|---|---|---|---|
| OCM | average 598 (SD 93) g | 42 ± 12 | 34, 64% | 42 ± 8 | 7 (13%) |
| Controls with obesity | 35 ± 5 |
Value
OCMaverage 598 (SD 93) g
Controls with obesity— not stated in the abstract
Mean age at death
OCM42 ± 12
Controls with obesity— not stated in the abstract
Male
OCM34, 64%
Controls with obesity— not stated in the abstract
BMI
OCM42 ± 8
Controls with obesity35 ± 5
LV fibrosis
OCM7 (13%)
Controls with obesity— not stated in the abstract
- Males died younger than females in OCM (40 ± 13 vs 45 ± 10)
- P = 0.036
- Increased RV and LV wall thickness in OCM vs controls
- all P < 0.05
Observational data: associations, not effects.
Original publication
Obesity Cardiomyopathy in Sudden Cardiac Death: A Distinct Entity? A Comparative Study. JACC Adv. Published 28 July 2023. doi:10.
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