Heart failure & cardiomyopathies
Obesity-Related Differences in Pathomechanism and Outcomes in Patients With Heart Failure with Preserved Ejection Fraction (HFpEF): A Cardiovascular Magnetic Resonance (CMR) Study
Authors' conclusion
CMR quantification of EAT and RV structure provides additive risk stratification for adverse outcomes in obese HFpEF.
Study context
- Population
- Patients with a clinical diagnosis of HFpEF undergoing CMR
- Participants
- 150 patients
- Exposure
- Obese vs nonobese HFpEF; EAT and right ventricle (RV) quantification by CMR
- Obesen = 73
- Nonobesen = 77reference
- Outcome
- Composite of:
- All-cause mortality
- First HF hospitalization
- Follow-up
- Median 46 months
Main finding
As reported in the abstract
Observational data: associations, not effects.
Further findings
Correlations in obese HFpEF
- EAT vs RV longitudinal strain
- r = 0.32, P = 0.006
- EAT and Total RV volume (TRVV) vs LV end-diastolic eccentric index
- r = 0.36, P = 0.002
Risk stratification in obese HFpEF (EAT + RV quantification)
- C-statistic increase
- 0.70 to 0.79
- Annual event rate, EAT<130 ml and TRVV<180 ml
- 3.2%
- Annual event rate, EAT ≥130 ml and TRVV ≥180 ml
- 11.8%; P < 0.001
Original publication
Obesity-Related Differences in Pathomechanism and Outcomes in Patients With HFpEF: A CMR Study. JACC Adv. Published 24 November 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →