Valvular & structural heart disease
Outcomes of patients with early calcific aortic valve disease detected by clinically indicated echocardiography
Main findingResult — go to the resultHazard ratio 2.9 95% CI 2.1–4.0Authors' conclusion
Patients with ASc are >25 times more likely to require AVI than those with no CAVD
Study context
- Population
- Patients aged ≥18 years with initial clinically indicated echocardiograms 2010–2018, excluding impaired right or left systolic ventricular function or other significant left-sided valve disease
- Participants
- 13,313 patients
- Exposure
- Aortic sclerosis or mild aortic stenosis (AS) vs no calcific aortic valve disease (CAVD)
- No CAVDn = 8,973reference
- Aortic sclerosis (ASc)n = 3,436
- Mild ASn = 455
- Outcome
- Composite of:
- CV death
- Aortic valve intervention (AVI)
- Follow-up
- Median 4.2 (IQR 1.8-6.7) years
Main finding
As reported in the abstract
Hazard ratio
2.9
95% CI 2.1–4.0
AScvs No CAVD
HR 2.9 (95% CI 2.1–4.0)
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Need for AVIAScvs No CAVDAdjusted for age and sex | 26.8 (9.1–79.1) | |
| 0.050.21520Hazard ratio (log scale) |
Clinical events in mild AS
- Clinical event rates accelerated after ∼5 years in those with mild AS
Original publication
Outcomes of patients with early calcific aortic valve disease detected by clinically indicated echocardiography. Eur Heart J Cardiovasc Imaging. Published 17 October 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →