Arrhythmias & electrophysiology
Phenotypic expression of rare progressive cardiac conduction disease variants in the general population
Main finding · Conduction diseaseResult — go to the resultHazard ratio 6.60 95% CI 3.14–13.8Authors' conclusion
In a population-based cohort, PCCD P/LP variant carriers were at greater risk of conduction disease.
Study context
- Population
- UK Biobank participants
- Participants
- 469,511 participants
- Exposure
- P/LP progressive cardiac conduction disease (PCCD) variant carriers vs non-carriers
- P/LPn = 25
- VUSn = 3,174
- Outcome
- Any conduction disease (lifetime risk, Cox models incl. rare variant status, sex, age)
Methodological detailspopulation-based, UK Biobank
- Population-based
- UK Biobank
Main finding
Conduction disease
Hazard ratio
6.60
95% CI 3.14–13.8
P < 0.001
By group
P/LPvs Non-carriers
HR 6.60 (95% CI 3.14–13.8); P < 0.001
As reported in the abstract
- C-index
- 0.602 (0.599-0.605)
Observational data: associations, not effects.
Further findings
| Outcome | HR (CI) | |
|---|---|---|
| AV blockP/LPvs Non-carriers | 23.2 (8.7–61.8) | |
| Pacemaker implantationP/LPvs Non-carriers | 13.4 (6.01–29.8) | |
| 0.050.21520Hazard ratio (log scale) |
Conduction disease model with P/LP status + PR-PRS and QRS-PRS
- C-index (improved model performance)
- 0.618 [0.615-0.622]
Original publication
Phenotypic expression of rare progressive cardiac conduction disease variants in the general population. Europace. Published 13 May 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →