HypertensionDiagnostic or prognostic study
Plasma Proteomics of Exercise Blood Pressure and Incident Hypertension
- Proteomic association study with external cohort validation and mendelian randomization
- multicohort
- cis-protein quantitative loci mendelian randomization
Authors' conclusion
Plasma proteomic profiling of EBP identified a novel protein, TGFBR3, which may protect against elevated BP and long-term CVD outcomes.
Study context
- Population
- Healthy participants free of cardiovascular disease (CVD) (HERITAGE Family Study) who underwent 2 cardiopulmonary exercise tests; incident hypertension tested in Framingham Heart Study (FHS), Jackson Heart Study (JHS) and Multi-Ethnic Study of Atherosclerosis (MESA)from 763 assessed
- Participants
- 681 participants
- Outcome
- Protein markers associated with exercise BP (EBP) and their association with incident hypertension
Performance
As reported in the abstract
Proteins associated with EBP and incident hypertension
Hazard ratio (95% CI)P value
TGFBR3incident hypertension, FHS
0.86(0.75–0.97)
P = 0.01TGFBR3incident hypertension, JHS
0.87(0.77–0.97)
P = 0.02TGFBR3incident hypertension, MESA
0.84(0.71–0.98)
P = 0.03TGFBR3incident hypertension, pooled cohort
0.86(0.79–0.92)
P = 6 × 10-5- TGFBR3 · exercise systolic BP (SBP)
- β estimate −3.39 (95% CI −4.79 to −2.00); P = 2.33 × 10-6
- Prostaglandin D2 synthase (PTGDS) · exercise diastolic BP (DBP)
- β estimate −2.50 (95% CI −3.29 to −1.70); P = 1.18 × 10-9
- Proteins identified by EBP profiling not identified through resting BP alone
- 34
Further findings
Genetically predicted TGFBR3 (cis-MR, ~700 000 individuals)
| Comparison | OR (95% CI) | P value | |
|---|---|---|---|
| TGFBR3 · hypertension | 0.99 (0.98–0.99) | P < 0.001 | |
| TGFBR3 · HF with hypertension | 0.86 (0.77–0.97) | P = 0.01 | |
| TGFBR3 · CVD | 0.84 (0.77–0.92) | P = 8 × 10-5 | |
| TGFBR3 · cerebrovascular events | 0.77 (0.70–0.85) | P = 5 × 10-7 | |
| 0.512Odds ratio (log scale) |
| Outcome | β (95% CI) | P value |
|---|---|---|
| Genetically predicted TGFBR3 (cis-MR, ~700 000 individuals) — TGFBR3 · SBP | −0.38 (−0.64 to −0.11) | P = 0.006 |
Original publication
Plasma Proteomics of Exercise Blood Pressure and Incident Hypertension. JAMA Cardiol. Published 1 August 2024. doi:10.1001/jamacardio.2024.1397
Summarised from the published abstract; every number is checked against it