Postdischarge major bleeding, myocardial infarction, and mortality risk after coronary artery bypass grafting
Authors' conclusion
The increase in mortality risk associated with a postdischarge major bleeding after CABG is substantial and is similar to the mortality risk associated with a postdischarge myocardial infarction.
Study context
- Population
- Patients undergoing first-time isolated coronary artery bypass grafting (CABG) in Sweden 2006–2017, surviving 14 days after dischargemedian follow-up 6.0 years
- Participants
- 36,633 patients
- Exposure
- Postdischarge major bleeding or MI vs none, mortality risk
- Major bleedingn = 2,429
- MIn = 2,231
- Outcome
- Mortality risk after postdischarge major bleeding and after postdischarge MI
- Follow-up
- <30 days, 30-365 days and >365 days after the event
Methodological detailsnationwide registry-based, SWEDEHEART Registry
- Nationwide registry-based
- SWEDEHEART Registry
Main finding
As reported in the abstract
Mortality after postdischarge major bleeding
Major bleeding
6.6%
2429
Major bleedingAdjusted hazard ratio (95% CI)
<30 days after event
20.2(17.3–23.5)
30-365 days after event
3.8(3.4–4.3)
>365 days after event
1.8(1.7–2.0)
Observational data: associations, not effects.
Further findings
Mortality after postdischarge MI
| MI | aHR (95% CI) | ||
|---|---|---|---|
| MI<30 days after event | 6.1% | 20.0 (16.7–23.8) | |
| MI30-365 days after event | 4.1 (3.6–4.8) | ||
| MI>365 days after event | 1.8 (1.7–2.0) | ||
| 0.050.21520Adjusted hazard ratio (log scale) |
Original publication
Postdischarge major bleeding, myocardial infarction, and mortality risk after coronary artery bypass grafting. Heart. Published 26 December 2023. doi:10.
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