Valvular & structural heart disease
Posterior Leaflet Restoration for Secondary Mitral Regurgitation: EXPLORE Mitral Regurgitation (MR) Results
Authors' conclusion
PLR with the MRace implant achieves substantial MR reduction and meaningful functional improvement, most pronounced in patients without severely enlarged left ventricles. (XPLORE MRace [BR]: Early Feasibility Experience of Posterior Leaflet Restoration to Reduce Mitral Regurgitation Using the MRace Implant [EXPLORE MRace]; NCT06113354).
Study context
- Population
- Symptomatic patients with severe secondary MR (≥3+)
- Participants
- 78 patients
- Comparison
- Nonseverely enlarged left ventricle (NSELV) compared with the severely enlarged left ventricle (SELV) group
- NSELVn = 46
- SELVn = 32
- Outcome
- 30-day mortality
- Follow-up
- 30 days
Methodological detailsstratified post hoc by left ventricular end-diastolic volume
- Stratified post hoc by left ventricular end-diastolic volume
Main finding
As reported in the abstract
All-cause mortality at 30 days
6.4%
Secondary outcomes
MR ≤1+ · 30 days and 1 year
30 days
1 year
| Outcome | NSELV | SELV |
|---|---|---|
| NYHA functional class I or II | 8.7% to 84.2% | 15.6%-76.9% |
| 6-minute walk test (paired patients)Δ, m | +93.9 | −7.8 |
Implant deployment
- The implant was successfully deployed
- 96.2%
MR ≤2+ · 30 days and 1 year
- MR ≤2+ at 30 days
- 93.8%
- MR ≤2+ sustained at 1 year
- 90.6%
Safety
Kaplan-Meier 1-year all-cause mortality
- Kaplan-Meier 1-year all-cause mortality — Overall
- 29.5%
Original publication
Posterior Leaflet Restoration for Secondary Mitral Regurgitation: EXPLORE MR Results. JACC Cardiovasc Interv. Published 31 October 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →