Arrhythmias & electrophysiology
Predictors of nonpulmonary vein triggers for atrial fibrillation: A clinical risk score
Authors' conclusion
A risk score incorporating predictors for NPVTs may allow provocation of triggers to be performed in patients with greatest expected yield.
Study context
- Population
- Consecutive patients undergoing atrial fibrillation (AF) ablation, Hospital of the University of Pennsylvania, January 2021–December 2022
- Participants
- 1,530 AF ablations
- Outcome
- Presence of NPVTs (non-pulmonary vein ectopic beats triggering AF or focal atrial tachycardia)
Methodological detailssingle-centre registry, derivation (80%) and validation (20%) sets
- Single-centre registry
- Derivation (80%) and validation (20%) sets
Main finding
As reported in the abstract
Risk factors for NPVTs (multivariable, derivation set) and PRE2SSS2 score
- Non-pulmonary vein triggers (NPVTs) observed
- 235 (15.4%)
- Female sex, OR
- 1.40 (95% CI 0.96-2.03; P = .080)
- Sinus node dysfunction, OR
- 1.67 (95% CI 0.98-2.87; P = .060)
- Previous AF ablation, OR
- 2.50 (95% CI 1.70-3.65; P <.001)
- Left atrial scar, OR
- 2.90 (95% CI 1.94-4.36; P <.001)
- PRE2SSS2 score AUC in validation cohort
- 0.728 (95% CI 0.648-0.807)
Observational data: associations, not effects.
Original publication
Predictors of nonpulmonary vein triggers for atrial fibrillation: A clinical risk score. Heart Rhythm. Published 29 January 2024. doi:10.
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