Heart failure & cardiomyopathies
Predictors of Outcome in a Contemporary Cardiac Sarcoidosis Population: Role of Brain Natriuretic Peptide, Left Ventricular Function and Myocardial Inflammation
Authors' conclusion
Cardiac sarcoidosis is associated with significant morbidity and mortality, particularly in those with cardiac involvement as the first manifestation. Higher BNP levels, lower LVEF and more active myocardial inflammation were independent predictors of outcomes.
Study context
- Population
- Consecutive patients with cardiac sarcoidosis with baseline laboratory testing, ECG, echocardiography, cardiac magnetic resonance (CMR) and FDG-PET
- Participants
- 319 patients
- Outcome
- Composite of:
- All-cause mortality
- Aborted SCD
- Major ventricular arrhythmic events
- HF hospitalisation
- Heart transplantation
- Follow-up
- Median 2.2 years (range: 1 month-11 years)
Methodological detailssingle-centre, consecutive patients
- Single-centre
- Consecutive patients
Main finding
As reported in the abstract
Independent predictors of composite endpoint (multivariate analysis)
Hazard ratio (95% CI)P value
Serum BNP levels
2.41(1.34–4.31)
P = 0.003CMR LVEF
0.96(0.94–0.98)
P < 0.0001Maximum standardized uptake value of FDG-PET
1.11(1.04–1.19)
P = 0.001- Composite endpoint reached
- 33%
Observational data: associations, not effects.
Further findings
All-cause mortality
- Died during follow-up
- 8%
- Annualized mortality rate
- 2.7%
- 5-year mortality rate
- 6.2%
- 10-year mortality rate
- 7.5%
Original publication
Predictors of Outcome in a Contemporary Cardiac Sarcoidosis Population: Role of Brain Natriuretic Peptide, Left Ventricular Function and Myocardial Inflammation. Eur J Heart Fail. Published 7 November 2023. doi:10.
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