Heart failure & cardiomyopathies
Economic Modeling Analysis of an Intensive Guideline-directed Medical Therapy (GDMT) Optimization Program in Hospitalized Heart Failure Patients
Authors' conclusion
An intensive GDMT optimization program for patients hospitalized with HF with reduced ejection fraction would be cost-effective and result in substantial gains in clinical outcomes, especially with the use of optimal quadruple GDMT.
Study context
- Population
- Hospitalized patients with HFrEF (STRONG-HF trial participants; Get With The Guidelines-HF registry patients admitted with worsening heart failure (HF))
- Comparison
- Intensive GDMT optimization program vs usual care
- Outcome
- Incremental cost-effectiveness ratio per quality-adjusted life-year
- Follow-up
- Lifetime time horizon
Methodological detailsMarkov model cost-effectiveness analysis, 2-state Markov model, clinical trial and real-world population models, US health care sector perspective, lifetime time horizon
- Markov model cost-effectiveness analysis
- 2-state Markov model
- Clinical trial and real-world population models
- US health care sector perspective
- Lifetime time horizon
Main finding
As reported in the abstract
ICER per quality-adjusted life-year
| Group | Value | Clinical trial model | Real-world model |
|---|---|---|---|
| Intensive GDMT optimization | ICER <$10 000 per quality-adjusted life-year | ||
| Optimal quadruple GDMT | $60 000 | $54 000 |
Value
Intensive GDMT optimizationICER <$10 000 per quality-adjusted life-year
Optimal quadruple GDMT— not stated in the abstract
Clinical trial model
Intensive GDMT optimization— not stated in the abstract
Optimal quadruple GDMT$60 000
Real-world model
Intensive GDMT optimization— not stated in the abstract
Optimal quadruple GDMT$54 000
Original publication
Economic Modeling Analysis of an Intensive GDMT Optimization Program in Hospitalized Heart Failure Patients. Circ Heart Fail. Published 6 November 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →