Arrhythmias & electrophysiology
Proarrhythmic drugs, drug levels, and polypharmacy in victims of sudden arrhythmic death syndrome: An autopsy-based study from Denmark
Authors' conclusion
The majority of the SADS population had a positive toxicology screening result, with a notably large proportion having proarrhythmic drugs and polypharmacy.
Study context
- Population
- Sudden arrhythmic death syndrome (SADS) victims aged 1–35 y (2000–2019) and 36–49 y (2007–2019) in Denmark, with autopsy and toxicology screening
- Participants
- 477 SADS victims
- Outcome
- Toxicologic profiles: proarrhythmic drugs, drug levels and polypharmacy
Methodological detailsnationwide
- Nationwide
Main finding
As reported in the abstract
Toxicologic profiles of SADS victims
- Positive toxicology screening (adjudicated nonlethal)
- 313 (66%)
- Average drugs per positive case
- 2.8
- QT-prolonging or brugadogenic drugs present (positive screening)
- More than half
- Polypharmacy
- 66%
- Psychotropic polypharmacy
- 37%
- QT-prolonging polypharmacy
- 22%
Original publication
Proarrhythmic drugs, drug levels, and polypharmacy in victims of sudden arrhythmic death syndrome: An autopsy-based study from Denmark. Heart Rhythm. Published 11 May 2024. doi:10.
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