Arrhythmias & electrophysiology
Prognostic Value of Left Atrial Calcification After Catheter Ablation for Atrial Fibrillation
Main findingResult — go to the resultAdjusted hazard ratio 2.81 95% CI 1.16–6.84Authors' conclusion
The presence of LAC was a significant and independent prognostic factor for identifying major adverse cardiovascular events after AF ablation.
Study context
- Population
- Atrial fibrillation (AF) patients with computed tomography (CT) and serial transthoracic echocardiography, January 2010–November 2017218 with AF ablation
- Participants
- 534 patients
- Exposure
- Left atrial calcification (LAC) vs no LAC after AF ablation
- LACn = 30
- Outcome
- Composite of:
- CV death
- Hospitalization for worsening HF
- Ischemic stroke
- Follow-up
- Median 5.8 years
Main finding
As reported in the abstract
Adjusted hazard ratio
2.81
95% CI 1.16–6.84
P = 0.02
Events by group
LAC
39.8 per 1,000 person-years
11 of 30
Non-LAC
8.9 per 1,000 person-years
10 events
LACvs Non-LAC
adjusted HR 2.81 (95% CI 1.16–6.84); P = 0.02
Observational data: associations, not effects.
Further findings
AF ablation and development of LAC (multivariable)
| OR (95% CI) | ||
|---|---|---|
| AF ablation | 11.8 (2.03–227.65) | |
| 0.050.21520Odds ratio (log scale) |
Predictors of LAC in AF-ablation patients
| HR (95% CI) | ||
|---|---|---|
| Prior stroke | 2.73 (1.08–6.93) | |
| Multiple ablation procedures | 4.21 (1.63–10.87) | |
| 0.050.21520Hazard ratio (log scale) |
Prevalence of LAC (all AF patients)
- LAC in all patients
- 31 (5.8%)
- LAC in AF-ablation patients
- 30 (13.8%)
Original publication
Prognostic Value of Left Atrial Calcification After Catheter Ablation for Atrial Fibrillation. JACC Clin Electrophysiol. Published 18 January 2023. doi:10.
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