Valvular & structural heart disease

Prognostic value of left ventricular myocardial work indices in patients with severe aortic stenosis undergoing transcatheter aortic valve replacement

Eur Heart J Cardiovasc ImagingPublished Prognostic cohort study

Performance · All-cause mortalityResult — go to the resultHazard ratio 0.639 95% CI 0.463–0.883

Authors' conclusion

LV GWI is independently associated with all-cause mortality in patients undergoing TAVR and has a higher prognostic value compared to both conventional and advanced parameters of LV systolic function.

Study context

Population
Patients with severe aortic stenosis (AS) undergoing transcatheter aortic valve replacement (TAVR)64 died
Participants
281 patients
Outcome
All-cause mortality
Follow-up
Median 52 (IQR 41-67) months

Performance

As reported in the abstract

Hazard ratio

0.639

95% CI 0.463–0.883

P = 0.007

LV GWI (per-tertile increase)
HR 0.639 (95% CI 0.463–0.883); P = 0.007

Per-tertile increase, as printed

Further findings

Baseline left ventricular (LV) myocardial work indices · before TAVR

LV GWI mean ± SD
1872 ± 753 mmHg%
GCW mean ± SD
2240 ± 797 mmHg%
GWW median (IQR)
200 (IQR 127-306) mmHg%
GWE median (IQR)
89 (IQR 84-93)%

Original publication

Prognostic value of left ventricular myocardial work indices in patients with severe aortic stenosis undergoing transcatheter aortic valve replacement. Eur Heart J Cardiovasc Imaging. Published 6 July 2023. doi:10.1093/ehjci/jead157

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