Arrhythmias & electrophysiology
Empirical Cavotricuspid Isthmus Ablation in Congenital Heart Disease: A Nationwide Prospective Study
Main finding · Freedom from any atrial arrhythmia recurrenceResult — go to the resultHazard ratio 0.47 95% CI 0.24–0.92Authors' conclusion
Empirical CTI ablation is associated with improved freedom from atrial arrhythmia and reduced rehospitalization in CHD patients.
Study context
- Population
- Congenital heart disease (CHD) patients referred for a first catheter ablation of an atrial arrhythmia between 2020 and 2024, without cavotricuspid isthmus (CTI)-dependent flutterstudy population, of 575 patients undergoing a first catheter ablation for atrial arrhythmia, 345 (60.0%) had CTI-dependent flutter and are not in the study population
- Participants
- 230 patients
- Exposure
- Empirical CTI ablation vs no empirical CTI ablation
- Empirical CTI ablationn = 71
- Outcome
- Freedom from any atrial arrhythmia recurrence
- Follow-up
- 1 year and 2 years
Main finding
As reported in the abstract
Hazard ratio
0.47
95% CI 0.24–0.92
P = 0.027
By group
Empirical CTI ablation
- 1 year
- 78.1%
- 2 years
- 71.2%
No empirical CTI ablation
- 1 year
- 65.6%
- 2 years
- 56.1%
1 year
Empirical CTI ablation78.1%
No empirical CTI ablation65.6%
2 years
Empirical CTI ablation71.2%
No empirical CTI ablation56.1%
Empirical CTI ablationvs No empirical CTI ablation
HR 0.47 (95% CI 0.24–0.92); P = 0.027
Observational data: associations, not effects.
Secondary outcomes
Arrhythmia-related hospitalization
- Arrhythmia-related hospitalization: P = 0.048
Study population characteristics
- Mean age
- 48.2 ± 16.4 years
- Male
- 50.9%
- CHD complexity moderate
- 57.4%
- Atrial macro-re-entry
- 53.0%
- Atrial fibrillation
- 47.0%
- Focal atrial tachycardia
- 17.4%
- Multiple arrhythmias
- 16.5%
Original publication
Empirical Cavotricuspid Isthmus Ablation in Congenital Heart Disease: A Nationwide Prospective Study. JACC Clin Electrophysiol. Published 1 September 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →