Heart failure & cardiomyopathiesSecondary analysis
Proteomic patterns according to ejection fraction: an EMPEROR-programme analysis
- Secondary analysis of the EMPEROR-Preserved and EMPEROR-Reduced randomised trials
- proteomic analysis
- False-discovery-rate (FDR) correction
Authors' conclusion
Within EMPEROR-Preserved, the top differentially expressed circulating proteins suggest that pathways related to natriuretic peptides, cell-adhesion, and clonal haematopoiesis are overexpressed at mildly-reduced ejection fraction, but none of the proteins passed the 5%FDR cut-off, and the correlation between circulating proteins and LVEF was weak.
Study context
- Population
- HF patients in the EMPEROR-Programme with proteomic measurements (1134 proteins, Olink); main analyses in EMPEROR-Preserved
- Participants
- 2,254 patients
- Comparison
- Protein concentrations across left ventricular ejection fraction (LVEF) categories
Primary result
As reported in the abstract
Proteins with a trend of expression across LVEF categories (EMPEROR-Preserved, top 10)
- Proteins with a trend across LVEF categories after adjustment and multiplicity correction
- 297
- NT-pro BNP, β
- 0.18 (0.09-0.27) (95% CI)
- Wnt inhibitory factor-1, β
- 0.40 (0.19-0.61) (95% CI)
- Sialomucin core protein 24, β
- 0.48 (0.22-0.74) (95% CI)
- Phospholipid transfer protein, β
- 0.38 (0.17-0.59) (95% CI)
- Natriuretic peptides B, β
- 0.13 (0.06-0.20) (95% CI)
- Intercellular adhesion molecule 5, β
- 0.31 (0.14-0.49) (95% CI)
- Neural cell adhesion molecule 2, β
- 0.45 (0.19-0.70) (95% CI)
- Neural cell adhesion molecule L1-like protein, β
- 0.45 (0.19-0.71) (95% CI)
- Interactor protein for cytohesin exchange factors 1, β
- 0.12 (0.05-0.19) (95% CI)
- 3-ketoacyl-CoA thiolase, peroxisomal, β
- 0.17 (0.07-0.26) (95% CI)
Further findings
Correlation of top proteins with LVEF
- Generally weak correlation
- Rho ≤0.2
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Proteomic patterns according to ejection fraction: an EMPEROR-programme analysis. Eur J Heart Fail. Published 13 January 2026. doi:10.1093/ejhf/xuag013
Summarised from the published abstract; every number is checked against it