Heart failure & cardiomyopathiesCohort study
Proteomic Prediction of Incident Heart Failure and Its Main Subtypes
- Prospective cohort study
- population-based
- external replication cohort
Authors' conclusion
A small number of circulating proteins accurately predicted future HF in the AGES-RS cohort of older adults, and they alone encompass the risk information found in a collection of clinical data.
Study context
- Population
- Older adults in the population-based Age, Gene/Environment Susceptibility Reykjavik Study (AGES-RS) cohort440 developed heart failure (HF)
- Outcome
- Prediction of incident HF, HFrEF and HFpEF by serum proteins (C-index)
Main finding
As reported in the abstract
Discrimination of protein panels (8-10 proteins) for incident HF
C-index, all incident HF
0.80
C-index, incident HFpEF
0.78
C-index, incident HFrEF
0.80
Observational data: associations, not effects.
Further findings
Incident HF subtypes
- HFrEF cases
- 167
- HFpEF cases
- 188
Protein panels vs clinical information and NT-proBNP-based models
- Protein panels alone encompassed the risk in clinical information and improved models based on NT-proBNP and clinical risk factors
Prediction by time to HF event
- Protein predictors performed particularly well close to the time of an HF event; replicated in the Cardiovascular Health Study
Original publication
Proteomic Prediction of Incident Heart Failure and Its Main Subtypes. Eur J Heart Fail. Published 18 December 2023. doi:10.1002/ejhf.3086
Summarised from the published abstract; every number is checked against it