Pulmonary vascular disease & thromboembolismDiagnostic or prognostic study
Pulmonary Artery Strain Predicts Prognosis in Pulmonary Arterial Hypertension
- Prognostic cohort study
- registry-based
- Cardiac magnetic resonance (CMR) feature tracking
Authors' conclusion
PA GLS confers incremental prognostic utility over the established risk scores for identifying patients with PAH at higher risk of death
Study context
- Population
- Patients with pulmonary arterial hypertension (PAH) from the ASPIRE and INITIATE registriesplus 82 normal controls
- Participants
- 169 patients
- Comparison
- Pulmonary artery (PA) global longitudinal strain (GLS) <9% vs ≥9%
- Outcome
- All-cause mortality
- Follow-up
- Median 34 months
Performance
As reported in the abstract
Hazard ratio
2.93
P = 0.010
- Higher mortality with PA GLS <9% vs ≥9%
- P < 0.001
- Deaths
- 45 (26.6%)
Further findings
Mean
| Outcome | Normal controls | PAH | P value |
|---|---|---|---|
| PA GLS, PAH vs normal controls | 23% (SD 6%) | 10% (SD 5%) | P < 0.0001 |
Incremental prognostic value of PA GLS over risk scores
- Over REVEAL 2.0, global chi-square
- P = 0.001
- Over REVEAL 2.0, C statistic comparison
- P = 0.030
- Over COMPERA 2.0, global chi-square
- P = 0.001
- Over COMPERA 2.0, C statistic comparison
- P = 0.048
Original publication
Pulmonary Artery Strain Predicts Prognosis in Pulmonary Arterial Hypertension. JACC Cardiovasc Imaging. Published 12 April 2023. doi:10.1016/j.jcmg.2023.02.007
Summarised from the published abstract; every number is checked against it