Arrhythmias & electrophysiology
Pulsed Field Ablation Using Focal Contact Force–Sensing Catheters for Treatment of Atrial Fibrillation: 1-Year Outcomes of the ECLIPSE AF Study
Authors' conclusion
This study demonstrated that optimization of focal PFA with 3 contact force-sensing, solid-tip ablation catheters resulted in the progressive improvement of PV isolation durability at 3-month remapping and high freedom from atrial arrhythmia survival rates, providing a promising focal PFA treatment option integrated with current ablation workflows.
Study context
- Population
- Patients with paroxysmal or persistent AF undergoing pulmonary vein (PV) isolation80 (98%) remapped
- Participants
- 82 patients
- Outcome
- Freedom from atrial arrhythmia
- Follow-up
- 12 months
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
1 year
Focal pulsed field ablation (PFA)
80.2%
95% CI 69.7%–87.4%
Observational data: associations, not effects.
Further findings
Acute PV isolation
- PV isolation achieved in targeted veins
- 100% (322/322)
- First-pass isolation
- 92.2% (297/322)
Durable isolation at 90-day remapping, optimized PFA cohorts 3, 4 and 5
- Per-patient isolation, cohorts 3, 4, 5
- 60%, 73%, 81%
- Per-PV isolation, cohorts 3, 4, 5
- 84%, 90%, 92%
- Patients remapped
- 80 (98%)
Safety
Primary safety events
- Primary safety events in 4 patients
- 4.9%, 4/82
- Nonembolic stroke (tamponade secondary to catheter perforation)
- 1
- Hemorrhagic vascular access complications
- 3
- Fistula, diaphragmatic paralysis, MI, pericarditis, thromboembolism, PV stenosis, TIA or death
- 0
Original publication
Pulsed Field Ablation Using Focal Contact Force–Sensing Catheters for Treatment of Atrial Fibrillation: 1-Year Outcomes of the ECLIPSE AF Study. Circ Arrhythm Electrophysiol. Published 19 December 2024. doi:10.
Summarised from the published abstract; every number is checked against it