Arrhythmias & electrophysiology
Pulsed field ablation using focal contact force-sensing catheters for treatment of atrial fibrillation: acute and 90-day invasive remapping results
Authors' conclusion
ECLIPSE AF demonstrated that optimized PFA using the CENTAURI System with three commercial, contact force-sensing, solid-tip focal ablation catheters resulted in transmural lesion formation and high proportion of durable PVI with a favourable safety profile, thus providing a viable treatment option for AF that integrates with contemporary focal ablation workflows.
Study context
- Population
- Patients with paroxysmal or persistent atrial fibrillation (AF) undergoing pulsed field ablation (PFA) with the CENTAURI System and focal contact force-sensing catheters (TactiCath SE, StablePoint, ThermoCool ST)80 (98%) remapped
- Participants
- 82 patients
- Exposure
- Cohorts 1 and 2 vs Cohorts 3-5
- Outcome
- Safety and acute and chronic PVI durability (invasive remapping)
- Follow-up
- 90 days
Methodological detailsmulticentre, two centres, Patients analysed in five cohorts based upon ablation settings, catheter and mapping system
- Multicentre
- Two centres
- Patients analysed in five cohorts based upon ablation settings, catheter and mapping system
Main finding
As reported in the abstract
Durable PVI on invasive remapping
| Group | Per-patient isolation | Per-PV isolation |
|---|---|---|
| Cohort 1 | 38% | 47% |
| Cohort 2 | 26% | 53% |
| Cohort 3 | 60% | 84% |
| Cohort 4 | 73% | 90% |
| Cohort 5 | 81% | 92% |
Per-patient isolation
Cohort 138%
Cohort 226%
Cohort 360%
Cohort 473%
Cohort 581%
Per-PV isolation
Cohort 147%
Cohort 253%
Cohort 384%
Cohort 490%
Cohort 592%
Observational data: associations, not effects.
Further findings
Acute pulmonary vein isolation (PVI)
- PVI achieved in PVs
- 100% (322/322)
- First-pass isolation
- 92.2% (297/322)
Safety
- Serious adverse events of interest
- 4
- Vascular access complications
- 3
- Lacunar stroke
- 1
Original publication
Pulsed field ablation using focal contact force-sensing catheters for treatment of atrial fibrillation: acute and 90-day invasive remapping results. Europace. Published 19 June 2023. doi:10.
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