Radiomics Analysis of Chronic Total Occlusion (CTO) Plaques for Predicting Successful Guidewire Crossing Within 30 Minutes of PCI
Authors' conclusion
CTO characteristics revealed by radiomics analysis can be used as effective imaging biomarkers for predicting guidewire success. However, the performance of the radiomics model depends on anatomic and operator factors.
Study context
- Population
- Patients with CTO undergoing PCI, retrospectively enrolled from one hospital (training and internal test sets) and from 2 other hospitals (external test sets)
- Participants
- 551 patients565 CTO lesions
- Comparison
- Radiomics model vs prior prediction models
- Outcome
- Successful guidewire crossing within 30 minutes (guidewire success) of CTO PCI
Methodological detailsretrospective, multicentre, internal and external test sets
- Retrospective
- Multicentre
- Internal and external test sets
Performance
As reported in the abstract
Guidewire success, external test set
| Test or model | AUC | Accuracy | Sensitivity | Specificity |
|---|---|---|---|---|
| Radiomics model | 0.86 | 74.58% | 81.58% | 61.90% |
Radiomics model
AUC0.86
Accuracy74.58%
Sensitivity81.58%
Specificity61.90%
- Radiomics model vs Prior prediction models: P < 0.05 — significantly higher; P<0.05 for all
Further findings
Guidewire success by data set
- Training set
- 203 of 357
- Internal test set
- 85 of 149
- External test set
- 38 of 59
Radiomics model performance by subgroup
- Performance dependent on calcification, CTO location, adjacent branch(es) and operator caseload
Original publication
Radiomics Analysis of CTO Plaques for Predicting Successful Guidewire Crossing Within 30 Minutes of PCI. Circ Cardiovasc Imaging. Published 20 August 2024. doi:10.
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