Acute cardiac care & resuscitation
Real-time hemodynamic responses to epinephrine and their association with return of spontaneous circulation (ROSC) in out-of-hospital cardiac arrest
Authors' conclusion
Greater delta DBP and delta MAP following epinephrine administration during cardiopulmonary resuscitation were associated with higher likelihood of achieving sustained ROSC in patients with OHCA.
Study context
- Population
- Patients with Out-of-hospital cardiac arrest (OHCA) treated at a tertiary hospital with invasive arterial blood pressure monitoring during resuscitation in the emergency departmentpatients included in the analysis
- Participants
- 160 patients
- Exposure
- Delta diastolic blood pressure (DBP), delta mean arterial pressure (MAP) and delta systolic blood pressure (SBP) after epinephrine administration in ROSC vs no-ROSC groups
- Outcome
- Sustained ROSC (ROSC maintained for at least 20 min)
Methodological detailstertiary hospital
- Tertiary hospital
Main finding
As reported in the abstract
Estimate (95% CI)P value
ROSCvs no-ROSC
median difference in delta DBP 13.7 mmHg(11.3–13.8)
P = 0.001ROSCvs no-ROSC
median difference in delta MAP 14.9 mmHg(12.6–15.7)
P = 0.001Observational data: associations, not effects.
Further findings
Sustained ROSC probability by delta DBP and delta MAP (restricted cubic spline)
- Positive associations of delta DBP and delta MAP with sustained ROSC probability
Sustained ROSC, multivariable analysis
- Adjusted odds ratio for delta DBP
- 1.02 (95% CI: 1.00-1.04, p = 0.040)
- Adjusted odds ratio for delta MAP
- 1.01 (95% CI: 1.00-1.03, p = 0.010)
Original publication
Real-time hemodynamic responses to epinephrine and their association with ROSC in out-of-hospital cardiac arrest. Resuscitation. Published 16 April 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →