Heart failure & cardiomyopathies
Relationship Between Serum Iron Level and Physical Function in Heart Failure Patients is Lost by Presence of Diabetes
Authors' conclusion
TSAT as a continuous variable, but not ID, was independently associated with physical function in HF patients, and a significant association was lost in patients with HF and DM
Study context
- Population
- Consecutive patients admitted for heart failure (HF) diagnosis and management
- Participants
- 562 patients
- Exposure
- Iron deficiency (ID) / transferrin saturation (TSAT) vs low physical function, by DM status
- Outcome
- Low physical function (short physical performance battery (SPPB) score <10 points)
Methodological detailsconsecutive patients, single-centre, propensity-score matched
- Consecutive patients
- Single-centre
- Propensity-score matched
Main finding
As reported in the abstract
Association of TSAT with low physical function, by DM (subgroups)
- Significant association between low TSAT and low physical function lost in HF patients with DM
- P for interaction < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | OR | P value |
|---|---|---|
| Predictors of low physical function (multivariate logistic regression)ID was not a predictor | 0.980 | P = 0.024 |
Prevalence of ID and low physical function
Patients
- ID
- 329 (58%)
- Low physical function
- 191 (34%)
Original publication
Relationship Between Serum Iron Level and Physical Function in Heart Failure Patients is Lost by Presence of Diabetes. ESC Heart Fail. Published 13 December 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →