Arrhythmias & electrophysiology
Renal Outcomes of Rhythm Control in Patients Recently Diagnosed With Atrial Fibrillation
Authors' conclusion
Among patients with AF and CKD, early rhythm control was associated with lower risks of adverse renal outcomes than rate control was.
Study context
- Population
- Patients recently diagnosed with atrial fibrillation (AF) with baseline estimated glomerular filtration rate (eGFR) data, Korea, 2005–2015; median age 62 years, 32.7% female2,213 (10.6%) with eGFR <60
- Participants
- 20,886 participants
- Exposure
- Early rhythm control vs rate control
- Outcome
- Primary composite outcome, by CKD status
Methodological detailspropensity overlap weighting, Korean National Health Insurance Service database
- Propensity overlap weighting
- Korean National Health Insurance Service database
Main finding
As reported in the abstract
Rhythm control
- Significant chronic kidney disease (CKD)
- 2.77 per 100 person-years
- No significant CKD
- 3.41 per 100 person-years
Rate control
- Significant CKD
- 3.92 per 100 person-years
- No significant CKD
- 3.21 per 100 person-years
Significant chronic kidney disease (CKD)
Rhythm control2.77 per 100 person-years
Rate control3.92 per 100 person-years
No significant CKD
Rhythm control3.41 per 100 person-years
Rate control3.21 per 100 person-years
Rhythm control vs Rate controlWeighted hazard ratio (95% CI)
Significant CKD
0.70(0.52–0.95)
No significant CKD
1.06(0.96–1.18)
Observational data: associations, not effects.
Safety
Safety outcomes
- No differences between rhythm and rate control, with or without significant CKD
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Renal Outcomes of Rhythm Control in Patients Recently Diagnosed With Atrial Fibrillation. JACC Clin Electrophysiol. Published 4 September 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →