Risk of cardiovascular events after influenza infection-related hospitalizations in adults with congenital heart disease: A nationwide population based study
Main finding · CV complicationsResult — go to the resultHazard ratio 2.48 95% CI 1.59–3.84Authors' conclusion
This pan-Canadian cohort study of adults with CHD demonstrated an association between influenza virus-related hospitalization and risk of cardiovascular complications during the 9 months post discharge.
Study context
- Population
- Adults aged 40 to 65 years with congenital heart disease (CHD), hospitalized 2010–2017, Canadian Congenital Heart Disease (CanCHD) databasematched cohort
- Participants
- 255 vs 255
- Exposure
- Influenza-related hospitalization vs limb fracture hospitalization
- Influenzan = 255
- Limb fracturen = 255reference
- Outcome
- CV complications: HF, acute MI, atrial arrhythmia, ventricular arrhythmia, heart block, myocarditis, pericarditis
Methodological detailsmatched 1:1 on age and calendar time, nationwide population based
- Matched 1:1 on age and calendar time
- Nationwide population based
Main finding
CV complications
Hazard ratio
2.48
95% CI 1.59–3.84
By group
Influenza
- Cumulative probability at 1 year
- 0.16
- Cumulative probability at 5 years
- 0.33
Limb fracture
- Cumulative probability at 1 year
- 0.03
- Cumulative probability at 5 years
- 0.15
Cumulative probability at 1 year
Influenza0.16
Limb fracture0.03
Cumulative probability at 5 years
Influenza0.33
Limb fracture0.15
Influenzavs Limb fracture
HR 2.48 (95% CI 1.59–3.84)
As reported in the abstract
Observational data: associations, not effects.
Original publication
Risk of cardiovascular events after influenza infection-related hospitalizations in adults with congenital heart disease: A nationwide population based study. Am Heart J. Published 4 September 2024. doi:10.
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