Risk Factors for Raised Left Ventricular Filling Pressure by Cardiovascular Magnetic Resonance: Prognostic Insights
Authors' conclusion
Raised CMR-modelled PCWP is an independent risk factor for incident HF and MACE.
Study context
- Population
- UK Biobank imaging substudy participants with cardiovascular magnetic resonance (CMR)
- Participants
- 39,163 participants
- Exposure
- Raised vs non-raised CMR-modelled pulmonary capillary wedge pressure (PCWP)
- Outcome
- Prognostic value of CMR-modelled PCWP for incident heart failure (HF) and major adverse cardiovascular events (MACE)
Methodological detailspopulation-based, UK Biobank imaging substudy, CMR-modelled PCWP from left atrial volume, LV mass and sex
- Population-based
- UK Biobank imaging substudy
- CMR-modelled PCWP from left atrial volume, LV mass and sex
Main finding
As reported in the abstract
CMR-modelled PCWPHazard ratio (95% CI)P value
Incident HF
2.91(2.07–4.07)
P < 0.001MACE
1.48(1.16–1.89)
P = 0.002Observational data: associations, not effects.
Further findings
Risk factors for raised CMR-modelled PCWP (≥15 mmHg)
| OR (95% CI) | P value | ||
|---|---|---|---|
| HypertensionIndependently associated | 1.57 (1.44–1.70) | P < 0.001 | |
| Male sexIndependently associated | 1.37 (1.26–1.47) | P < 0.001 | |
| Regular alcohol consumptionIndependently associated | 1.10 (1.02–1.19) | P = 0.012 | |
| 0.512Odds ratio (log scale) |
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Risk factors for raised CMR-modelled PCWP (≥15 mmHg)BMI · per SD increment · independently associated | 1.57 (1.52–1.62) | P < 0.001 | |
| Risk factors for raised CMR-modelled PCWP (≥15 mmHg)Age · per decade increment · independently associated | 1.33 (1.27–1.41) | P < 0.001 | |
| 0.512Odds ratio (log scale) |
Original publication
Risk Factors for Raised Left Ventricular Filling Pressure by Cardiovascular Magnetic Resonance: Prognostic Insights. ESC Heart Fail. Published 12 August 2024. doi:10.
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