Prevention & lipidsDiagnostic or prognostic study
Risk of Cardiovascular Events Using the SMART Polyvascular Disease Risk Score
- Development and validation of the SMART risk score
- Cox regression, accelerated failure time model, and survival analyses
- Baylor Scott & White EPIC informatics and data warehouse
Authors' conclusion
The SMART polyvascular disease risk score can provide accurate estimation of up to 10-year risk of CV events and could be potentially leveraged to develop individualized risk mitigation strategies.
Study context
- Population
- Patients at their first outpatient cardiology evaluation between April 2014 and October 2023 (mean age 60.9 ± 15.2 years, 48.6% females)study population, median follow-up 2.1 years (IQR: 0.54–4.4) · development cohort 60% · test cohort 40%
- Participants
- 259,250 patients
- Comparison
- SMART score vs an established risk prediction model
Performance
As reported in the abstract
Observed MACE event rates by SMART risk score group:
- All-cause death
- Ischemic stroke
- Nonfatal myocardial infarction (MI)
Further findings
Composition of major adverse CV events (MACE) in the very high-risk group
- Most MACE events were all-cause death, with nonfatal myocardial infarction and stroke also being high
Model performance · test cohort
- SMART score outperformed TRS2°P; C-statistic (as printed in the parenthesis with TRS2°P)
- 0.811
- The SMART risk score allowed accurate estimation of MACE
Original publication
Risk of Cardiovascular Events Using the SMART Polyvascular Disease Risk Score. JACC Adv. Published 2 January 2026. doi:10.1016/j.jacadv.2025.102508
Summarised from the published abstract; every number is checked against it