Arrhythmias & electrophysiology
Risk of malignant ventricular arrhythmias in patients with mildly to moderately reduced ejection fraction after permanent pacemaker implantation
Authors' conclusion
Patients with mildly to moderately reduced LVEF and multivessel CAD undergoing PPM implantation are at increased risk for the development of malignant ventricular arrhythmias.
Study context
- Population
- Patients with left ventricular ejection fraction (LVEF) 35%–49% undergoing permanent pacemaker implantation without an implantable cardioverter-defibrillator (ICD) indication
- Participants
- 243 patients
- Outcome
- Sustained VT/VF
- Follow-up
- Median 27 months
Main finding
As reported in the abstract
Patients meeting primary end point of VT/VF
11
4.5%
Observational data: associations, not effects.
Further findings
VT/VF with multivessel coronary artery disease (CAD)
| Values | Subhazard ratio (95% CI) | P value | ||
|---|---|---|---|---|
| Multivessel CADCompeting risks regression | Multivessel CAD 9.8% · Annualized risk 4.3% per year | 5.4 (1.5–20.1) | P = 0.01 | |
| 0.050.21520Subhazard ratio (log scale) |
Original publication
Risk of malignant ventricular arrhythmias in patients with mildly to moderately reduced ejection fraction after permanent pacemaker implantation. Heart Rhythm. Published 13 March 2024. doi:10.
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