Heart failure & cardiomyopathies
S2I2N0–3 Score Predicts Short- and Long-Term Mortality and Morbidity in HFrEF: A Post-Hoc Analysis of the GUIDE-IT Trial
Authors' conclusion
The S2I2N0-3 risk score had modest predictive values for both short- and long-term clinical outcomes in HFrEF patients, offering equivalent performance to the established MAGGIC score.
Study context
- Population
- Patients with HFrEF in the GUIDE-IT trial
- Participants
- 890 patients
- Comparison
- S2I2N0-3 score; vs MAGGIC score for prediction
- Primary endpoint
- CV death, all-cause death, HF hospitalization, any hospitalization, and composite of CV death and HF hospitalization
- Follow-up
- Short term (90 days) and long term (median 15 months)
Methodological detailspost-hoc analysis, Cox and competing risk models
- Post-hoc analysis
- Cox and competing risk models
Primary result
As reported in the abstract
Risk per point increment of S2I2N0-3 score (HR, short term; long term) · 90 days; median 15 months
- CV death, short term HR
- 1.43 (1.03-1.98) (95% CI)
- CV death, long term HR
- 1.18 (1.02-1.38) (95% CI)
- All-cause death, short term HR
- 1.52 (1.12-2.07) (95% CI)
- All-cause death, long term HR
- 1.18 (1.03-1.36) (95% CI)
- Heart failure (HF) hospitalization, short term HR
- 1.39 (1.20-1.62) (95% CI)
- HF hospitalization, long term HR
- 1.18 (1.06-1.31) (95% CI)
- Any hospitalization, short term HR
- 1.19 (1.06-1.34) (95% CI)
- Any hospitalization, long term HR
- 1.09 (1.00-1.19) (95% CI)
- CV death or HF hospitalization, short term HR
- 1.39 (1.21-1.60) (95% CI)
- CV death or HF hospitalization, long term HR
- 1.17 (1.06-1.30) (95% CI)
Further findings
Discrimination (C-index) across outcomes and time points
- C-indices range
- 0.619 to 0.753
Comparison with MAGGIC score (Z-statistics, NRI, IDI) · short and long term
- Comparable predictive power to MAGGIC for all outcomes
S2I2N0-3 risk strata (three groups) and adverse outcomes
- Significant positive associations between strata and adverse outcomes
Original publication
S2I2N0–3 Score Predicts Short- and Long-Term Mortality and Morbidity in HFrEF: A Post-Hoc Analysis of the GUIDE-IT Trial. ESC Heart Fail. Published 7 February 2024. doi:10.
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