Heart failure & cardiomyopathies
Sex and Age Differences in the Association Between Metabolic Dysfunction-Associated Fatty Liver Disease and Heart Failure: A Prospective Cohort Study
Authors' conclusion
MAFLD greatly increased the risk of HF in women, especially young women. With increasing age, MAFLD-related risk of HF decreased and the difference between men and women disappeared.
Study context
- Population
- Participants of the Kailuan Study2,939 developed heart failure (HF)
- Participants
- 96,576 participants
- Exposure
- Mild and significant MAFLD vs no MAFLD
- Outcome
- Incident HF, by sex and age
- Follow-up
- Median 14.0 years
Main finding
As reported in the abstract
HF, by sex and age (subgroups)
Each group vs Non-MAFLDHazard ratio (95% CI)
Significant-MAFLDwomen
1.84(1.43–2.37)
Significant-MAFLDmen
1.36(1.20–1.53)
Mild-MAFLDage <45 years
1.55(1.07–2.25)
Significant-MAFLDage <45 years
2.72(1.87–3.97)
Significant-MAFLDage >65 years
1.11(0.92–1.34)
- Risk differed by sex
- P for interaction < 0.05
- Risk differed by age
- P for interaction < 0.001
- MAFLD-associated HF risk decreased with age in men
- P for interaction < 0.05
- MAFLD-associated HF risk decreased with age in women
- P for interaction < 0.05
- Sex difference only in participants <45 years
- P for interaction < 0.05
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| HF, all participantsMild-MAFLDvs Non-MAFLDAdjusted for confounding factors | 1.27 (1.16–1.39) | |
| HF, all participantsSignificant-MAFLDvs Non-MAFLDAdjusted for confounding factors | 1.45 (1.31–1.63) | |
| 0.512Hazard ratio (log scale) |
Original publication
Sex and Age Differences in the Association Between Metabolic Dysfunction-Associated Fatty Liver Disease and Heart Failure: A Prospective Cohort Study. Circ Heart Fail. Published 13 February 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →