Heart failure & cardiomyopathies
Sex and Race Differences in Lifetime Risk of Heart Failure With Preserved Ejection Fraction and Heart Failure With Reduced Ejection Fraction
Authors' conclusion
Lifetime risks for HFpEF and HFrEF vary by sex, race, and history of antecedent myocardial infarction.
Study context
- Population
- Participants >45 years without prevalent HF at baseline, CHS and MESA cohortsmedian follow-up 11.6 years
- Participants
- 12,417 participants
- Comparison
- Lifetime risk of HF with preserved ejection fraction (HFpEF) and HF with reduced ejection fraction (HFrEF) by sex and race
- Outcome
- Remaining lifetime risk of HFpEF (EF ≥45%) and HFrEF (EF <45%), with mortality and the other HF subtype as competing risks
- Follow-up
- Index age 45 years through 90 years of age
Methodological detailsparticipant-level data, competing-risk modified Kaplan-Meier
- Participant-level data
- Competing-risk modified Kaplan-Meier
Pooled result
As reported in the abstract
Lifetime risk from index age 45 through 90 years
Any HF
| Outcome | Men | Women | Nonblacks | Blacks |
|---|---|---|---|---|
| HFrEF | 10.6% | 5.8% | — not stated in the abstract | — not stated in the abstract |
| HFpEF | — not stated in the abstract | — not stated in the abstract | 11.2% | 7.7% |
— not stated in the abstract
Further pooled results
Lifetime risk by antecedent MI before HF diagnosis
- HFpEF risk vs no antecedent MI
- up to 2.5-fold higher
- HFrEF risk vs no antecedent MI
- 4-fold higher
Original publication
Sex and Race Differences in Lifetime Risk of Heart Failure With Preserved Ejection Fraction and Heart Failure With Reduced Ejection Fraction. Circulation. Published 19 January 2018. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →