Sex Differences in Cardiac Troponin Trajectories Over the Life Course
Authors' conclusion
Trajectories of cardiac troponin differ between women and men in the general population, with differing associations to conventional risk factors and cardiovascular outcomes.
Study context
- Population
- General population (Whitehall II cohort); mean age 58±7 (women) and 57±7 (men) years
- Participants
- 2,142 vs 5,151
- Exposure
- Women vs men
- Womenn = 2,142
- Menn = 5,151reference
- Outcome
- Sex-specific cardiac troponin trajectories and their association with nonfatal MI, nonfatal stroke or CV death
- Follow-up
- Median 20.9 years
Methodological detailsWhitehall II cohort, hs-cTnI measured on 3 occasions over 15 years, linear mixed-effects models, multistate joint models
- Whitehall II cohort
- hs-cTnI measured on 3 occasions over 15 years
- Linear mixed-effects models
- Multistate joint models
Main finding
As reported in the abstract
Cardiac troponin trajectories by sex
P < 0.001
- Troponin persistently lower in women; relatively larger increase with age in women
- P for interaction < 0.001
- Sex interaction for troponin–body mass index (BMI) association
- P for interaction = 0.008
- Sex interaction for troponin–diabetes association
- P for interaction = 0.003
Observational data: associations, not effects.
Further findings
Composite of nonfatal MI, nonfatal stroke or CV death · median follow-up 20.9 years
Adjusted HR per 2-fold troponin difference (95% CI) Women 1.34 (1.17-1.52) · Men 1.30 (1.21-1.40)
Adjusted HR for troponin slope (95% CI) Women 2.70 (1.01-7.33) · Men 1.31 (0.62-2.75)
- Composite of nonfatal MI, nonfatal stroke or CV death: troponin concentration: Pinteraction=0.752
- Composite of nonfatal MI, nonfatal stroke or CV death: troponin slope: Pinteraction=0.250
Original publication
Sex Differences in Cardiac Troponin Trajectories Over the Life Course. Circulation. Published 28 April 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →