Acute cardiac care & resuscitation
Sex-Related Prognosis of VA-ECMO–Treated Cardiogenic Shock: A Post Hoc Analysis of the HYPO-ECMO Trial
Authors' conclusion
In this post hoc analysis of the HYPO-ECMO trial, male and female patients experienced similar outcomes in cardiogenic shock treated with venoarterial extracorporeal membrane oxygenation. Sex did not significantly modify the effect of moderate hypothermia on outcomes.
Study context
- Population
- Patients with cardiogenic shock receiving venoarterial extracorporeal membrane oxygenationpatients enrolled in the trial
- Participants
- 334 patients
- Comparison
- Clinical outcomes were compared by sex
- Femalen = 81
- Primary endpoint
- 30-day all-cause mortality
- Follow-up
- 30 days
Primary result
As reported in the abstract
- Adjusted odds ratio (direction of comparison not stated)
- 1.01 [0.57-1.78]; P =0.98
- Log-rank test
- P = 0.93
Secondary outcomes
| Outcome | Female | Male |
|---|---|---|
| Effect of moderate hypothermia on the primary outcome, by sex · 30 days | ||
| Adjusted odds ratio | 0.67 [0.26-1.76]; P =0.41 | 0.73 [0.43-1.25]; P =0.25 |
- Effect of moderate hypothermia on the primary outcome, by sex: interaction P =0.88
All-cause mortality · 60 and 180 days
- Adjusted odds ratio, 60 days (direction of comparison not stated)
- 0.87 [0.49-1.52]; P =0.61
- Adjusted odds ratio, 180 days (direction of comparison not stated)
- 0.83 [0.47-1.46]; P =0.51
- No significant sex differences
Composite of all-cause mortality, heart transplant, escalation to left ventricular assist device implantation, or stroke · up to 180 days
- No significant sex differences
- P > 0.2 for all
Effect of moderate hypothermia on the primary outcome, by sex · 30 days
- Not modified by sex
Effect of moderate hypothermia on secondary outcomes, by sex
- Not modified by sex
- interaction P >0.3 for all
Original publication
Sex-Related Prognosis of VA-ECMO–Treated Cardiogenic Shock: A Post Hoc Analysis of the HYPO-ECMO Trial. Circ Heart Fail. Published 20 May 2025. doi:10.
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