SGLT2 inhibitors and cardiovascular outcomes in patients with acute myocardial infarction: a retrospective cohort analysis
Main finding · Recurrent AMIResult — go to the resultAdjusted odds ratio 0.459 95% CI 0.367–0.551Authors' conclusion
SGLT2-Is are associated with improved cardiovascular outcomes in patients with AMI, including reductions in recurrent AMI, all-cause hospitalizations and mortality, and cardiac arrest. These findings emphasize the need for prospective clinical trials involving patients with AMI and other cardiovascular comorbidities, regardless of LVEF, to confirm these results.
Study context
- Population
- Patients aged ≥18 with acute myocardial infarction (AMI) identified via ICD-10 codes regardless of left ventricular ejection fraction (LVEF), categorized by SGLT2-Is usepatients analysed after propensity score matching (PSM)
- Participants
- 89,554 patients
- Exposure
- SGLT2-Is use vs non-use among patients with AMI
- SGLT2-Is usersn = 44,777
- Non-usersn = 44,777reference
- Outcome
- Recurrent AMI
- Follow-up
- 1 year
Methodological detailspropensity score matching (PSM), TriNetX data
- Propensity score matching (PSM)
- TriNetX data
Main finding
As reported in the abstract
Adjusted odds ratio
0.459
95% CI 0.367–0.551
SGLT2-Is usersvs non-users
aOR 0.459 (95% CI 0.367–0.551)
Observational data: associations, not effects.
Secondary outcomes
Mean follow-up duration
| Outcome | aOR (95% CI) | |
|---|---|---|
| All-cause hospitalizations (secondary)Lower with SGLT2-Is use | 0.782 (0.762–0.803) | |
| All-cause mortality (secondary)Lower with SGLT2-Is use | 0.640 (0.612–0.670) | |
| Cardiac arrest (secondary)Lower with SGLT2-Is use | 0.834 (0.773–0.900) | |
| 0.512Adjusted odds ratio (log scale) |
Acute heart failure (HF) hospitalizations, new-onset atrial fibrillation, stroke (secondary)
- No differences were observed
Original publication
SGLT2 inhibitors and cardiovascular outcomes in patients with acute myocardial infarction: a retrospective cohort analysis. Eur Heart J Cardiovasc Pharmacother. Published 26 April 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →