Heart failure & cardiomyopathies
Socio-Economic Status and the Effect of Guideline-Directed Medical Therapy in the STRONG-HF Study
Authors' conclusion
In this post hoc analysis of the STRONG-HF study, lower SES was associated with milder acute HF but similar 180-day outcomes. Higher SES patients benefitted more from HIC.
Study context
- Population
- Patients with acute heart failure (AHF), by socio-economic status (SES) measured by annual household income, years of education and medical insurance coverage
- Comparison
- Patients' baseline characteristics, outcomes (HF readmission, death and their composite) and the effect of high-intensity care (HIC) vs. usual care (UC) were examined by SES scores 0-2, 3 and 4-5
Primary result
As reported in the abstract
Baseline characteristics by SES · before discharge
- Lower SES patients were younger, predominantly female, Black and non-European, had fewer comorbidities such as atrial fibrillation, diabetes and ischaemic heart disease and exhibited milder HF (lower NYHA class, lower creatinine and higher cholesterol before discharge)
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| HF readmission or death · 180-daySES scores 3vs SES scores 0-2After adjusting for baseline characteristics · differences were not statistically significant | 0.75 (0.48–1.16) | |
| HF readmission or death · 180-daySES scores 4-5vs SES scores 0-2After adjusting for baseline characteristics · differences were not statistically significant | 0.85 (0.58–1.23) | |
| 0.512Hazard ratio (log scale) |
HR
| Outcome | SES scores 0-2 | SES scores 3 | SES scores 4-5 |
|---|---|---|---|
| Treatment effect of HIC by SES | 0.69 | 0.72 | 0.50 |
- Treatment effect of HIC by SES: Higher SES patients had numerically better treatment effect from HIC
Original publication
Socio-Economic Status and the Effect of Guideline-Directed Medical Therapy in the STRONG-HF Study. ESC Heart Fail. Published 12 February 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →