Acute cardiac care & resuscitation

Sub30: Feasibility study of a pre-hospital extracorporeal membrane oxygenation (ECMO) in patients with refractory out-of-hospital cardiac arrest in London, United Kingdom

ResuscitationPublished Prospective single-arm feasibility study

Authors' conclusion

Whilst our study did not meet primary outcome of achieving full ECPR flow within 30-minute of collapse, it demonstrated safe, timely and effective delivery of ECPR with comparable survival rates by pre-hospital teams in a large metropolitan city

Study context

Population
Patients with refractory OHCA in London, UK5 cannulated for ECPR
Participants
43 patients
Outcome
Established on pre-hospital ECPR within 30 min of the call to the emergency services
Methodological detailsopen-label, 43 eligible patients identified over 27 recruitment days in 13 months; ECPR team despatched to 18
  • Open-label
  • 43 eligible patients identified over 27 recruitment days in 13 months; ECPR team despatched to 18

Main finding

As reported in the abstract

Established on pre-hospital ECPR within 30 min of call

Pre-hospital ECPR

0

events

Observational data: associations, not effects.

Further findings

Time from initial collapse to ECPR full flows

Mean time from collapse to ECPR full flows, min (range 37-59)
47
  • Cannulated patients, n = 5

Travel time to scene

Median travel time to scene, min (range 3-20)
14

Treatment withdrawn

Treatment withdrawn (of 5 patients)
3

Survival to hospital discharge

Survived to hospital discharge (of 5 patients)
2
  • Both CPC score 3; Modified Rankin Score (mRS) 4 and 5 respectively

Original publication

Sub30: Feasibility study of a pre-hospital extracorporeal membrane oxygenation (ECMO) in patients with refractory out-of-hospital cardiac arrest in London, United Kingdom. Resuscitation. Published 5 December 2024. doi:10.1016/j.resuscitation.2024.110455

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