Subclinical coronary artery disease in Swiss HIV-positive and HIV-negative persons
Authors' conclusion
HIV-positive persons in Switzerland had a similar degree of non-calcified/mixed plaque and high-risk plaque, and may have less calcified coronary plaque, and lower coronary atherosclerosis involvement and severity scores than HIV-negative persons with similar Framingham risk scores.
Study context
- Population
- HIV-positive and HIV-negative persons referred for clinically indicated coronary CT angiography, Switzerland
- Participants
- 428 vs 276
- Exposure
- HIV-positive vs HIV-negative persons
- HIV-positiven = 428
- HIV-negativen = 276reference
- Outcome
- Subclinical atherosclerosis by coronary artery calcium (CAC) scoring and coronary CT angiography
Main finding
As reported in the abstract
Calcified plaque prevalence (multivariable adjusted)
HIV-positive vs HIV-negativeAdjusted odds ratio (95% CI)P value
Calcified plaque
0.57(0.40–0.82)
P < 0.01Coronary segment severity score
0.72(0.53–0.99)
P = 0.04Segment involvement score
0.71(0.52–0.97)
P = 0.03Observational data: associations, not effects.
Further findings
Baseline characteristics
Median age HIV-positive 52 years · HIV-negative 56 years
Median 10-year Framingham risk
- Baseline characteristics: age P < 0.01
- Baseline characteristics: Framingham P = 0.40
- Baseline characteristics: median HIV duration 15 years
Non-calcified/mixed plaque by advanced immunosuppression (HIV-positive)
- Advanced immunosuppression associated with non-calcified/mixed plaque, aOR
- 1.97 (95% CI 1.09-3.56; P = 0.02)
Original publication
Subclinical coronary artery disease in Swiss HIV-positive and HIV-negative persons. Eur Heart J. Published 24 March 2018. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →