Arrhythmias & electrophysiology
Subclinical device-detected atrial fibrillation and stroke risk: a systematic review and meta-analysis
Pooled result · Annual stroke rateResult — go to the resultFold increased risk 2.4 95% CI 1.8–3.3Authors' conclusion
Subclinical AF strongly predicts clinical AF and is associated with elevated absolute stroke risk albeit lower than risk described for clinical AF.
Study context
- Population
- Patients with cardiac implantable electronic devices (CIEDs)11 studies
- Comparison
- Subclinical atrial fibrillation (AF) > defined cut-off duration vs subclinical AF < cut-off duration
- Outcome
- Stroke risk in subclinical AF and temporal association between subclinical AF and stroke
Pooled result
Annual stroke rate
Fold increased risk
2.4
95% CI 1.8–3.3
P < 0.001
By group
Subclinical AF > cut-off
1.89/100 person-year
95% CI 1.02–3.52
Subclinical AF < cut-off
0.93/100 person-year
As reported in the abstract
Further pooled results
Association of subclinical AF with clinical AF
| OR (95% CI) | P value | ||
|---|---|---|---|
| Subclinical AFI2 = 0% | 5.7 (4.0–8.0) | P < 0.001 | |
| 0.10.31310Odds ratio (log scale) |
Prevalence of subclinical AF after CIED implant (unselected patients with pacing indication) · 1-2.5 years
- Subclinical AF prevalence
- 35% [IQR 34-42]
Annual stroke rate, studies with mean CHADS2 score 2.1 ± 0.1 (3 studies)
- Annual stroke rate with subclinical AF
- 2.76/100 person-years (95% CI 1.46-5.23)
Temporal relationship of subclinical AF and stroke
- Strokes in presence of ongoing AF (after excluding patients without AF)
- 17%
- Subclinical AF within 30 days preceding stroke
- 29% [IQR 8-57]
Original publication
Composed by AI from the published abstract and checked against it. How Briefs are made →